Pyridone-pyrimidine derivative acting as KRAS G12C mutein inhibitor

US11655248B2 · kind B2 · utility

Assignee

• Medshine Discovery Inc. · CN

Inventors

• Yaxian Cai · Shanghai, CN
• Zhaobing Xu · Shanghai, CN
• Hailong Yang · Beijing, CN
• Shiqi Han · Shanghai, CN
• Guoping HU · Shanghai, CN
• Lihong Hu · Shanghai, CN
• Charles Z. Ding · San Mateo, US
• Jian Li · Shanghai, CN
• Shuhui CHEN · Shanghai, CN

Key dates

• Filing date: Jan 27, 2021
• Grant date: May 23, 2023
• Expiry date: Jul 16, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.