Methods of enhancing the sialic acid content of a CHO-expressed recombinant glycoprotein
US11655457B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Jun 2, 2022 |
| Grant date | May 23, 2023 |
| Priority date | — |
| Expiry date | Jun 2, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In accordance with the present invention, CHO cells expressing a recombinant polypeptide of interest are grown in media where the amino acids, vitamins, phosphate, lipids and/or antioxidant optimization is utilized to manipulate and/or control the protein quality attributes of the polypeptides. Polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.