Antigen purification

US11655461B2 · kind B2 · utility

Assignee

• KBIO HOLDINGS LIMITED · GB

Inventors

• Steven D. Hume · Owensboro, US
• Leigh Burden · Owensboro, US
• Joshua D. Morton · Evansville, US
• Greg Pogue · Austin, US
• Barry Bratcher · Owensboro, US
• Hugh A. Haydon · Louisville, US
• Carrie A. Simpson · Evansville, US
• Nick Partain · Owensboro, US
• John W. Shepherd · Owensboro, US
• Kelsi Swope · Maceo, US

Key dates

• Filing date: Oct 5, 2020
• Grant date: May 23, 2023
• Expiry date: Oct 29, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/40063
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods and exemplary compositions associated with antigen purification, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; and a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection.