Universal platform for preparing an inhibitory chimeric antigen receptor (iCAR)
US11660315B2 · kind B2 · utility
0Cited by
2References
11Claims
0Family size
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Key dates
| Filing date | Sep 28, 2018 |
| Grant date | May 30, 2023 |
| Priority date | — |
| Expiry date | Feb 25, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of identifying a target for preparing an inhibitory chimeric antigen receptor (iCAR) or a protective chimeric antigen receptor (pCAR) capable of preventing or attenuating undesired activation of an effector immune cell. Also provided are a list of iCAR targets, as well as vectors and transduced effector immune cells comprising the nucleic acid molecule and methods for treatment of cancer comprising administering the transduced effector immune cells are further provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.