Microscale device and method for purification of radiopharmaceuticals
US11660571B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 14, 2017 |
| Grant date | May 30, 2023 |
| Priority date | — |
| Expiry date | Mar 3, 2039 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00986
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.