Indolizine compounds, preparation method and use thereof

US11661421B2 · kind B2 · utility

Assignee

• HAIHE BIOPHARMA CO., LTD. · CN

Inventors

• Xuxing Chen · Shanghai, CN
• Yi Chen · Shanghai, CN
• Ying-Huey Huang · Taipei, TW
• Meiyu Geng · Shanghai, CN
• Qiong Zhang · Plano, US
• Jian Ding · Shanghai, CN
• Yucai Yao · Shanghai, CN
• Qianqian Shen · Shanghai, CN
• Yanyan Shen · Lo Wu, CN

Key dates

• Filing date: Mar 5, 2019
• Grant date: May 30, 2023
• Expiry date: Sep 25, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides an indolizine compound represented by formula I or a pharmaceutically acceptable salt thereof, a preparation method and a use thereof. The indolizine compound has an inhibitory effect on wild-type and/or mutant EZH2 or EZH1, and is expected to be developed into a novel drug for anti-tumor or for the treatment of autoimmune diseases.