Purification of antibody drug conjugates using a sodium phosphate gradient
US11661438B2 · kind B2 · utility
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Key dates
| Filing date | Dec 7, 2016 |
| Grant date | May 30, 2023 |
| Priority date | — |
| Expiry date | Jan 25, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6851
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.