Human β2-glycoprotein I expression
US11661447B2 · kind B2 · utility
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Key dates
| Filing date | Aug 3, 2018 |
| Grant date | May 30, 2023 |
| Priority date | — |
| Expiry date | Oct 16, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/24
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided herein are compositions, systems, kits, and methods for expressing a peptide of interest, such as Apolipoprotein H (ApoH), also known as β2-glycoprotein I (β2GPI), at increased levels using a non-ApoH signal peptide (e.g., a signal peptide that permits increased protein export from cells). Also provided herein are compositions, systems, kits, and methods for employing such recombinant ApoH with a non-ApoH signal peptide to detect subject Apolipoprotein H antibodies in a sample from a subject (e.g., to diagnose antiphospholipid syndrome in a subject).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.