Optimized cross-species specific bispecific single chain antibody contructs

US11661462B2 · kind B2 · utility

Assignee

• AMGEN RESEARCH (MUNICH) GMBH · DE

Inventors

• Benno Rattel · Munich, DE
• Matthias Friedrich · Munich, DE
• Peter Kufer · Munich, DE
• Patrick Hoffmann · Munich, DE
• Tobias Raum · Munich, DE
• Markus Münz · Munich, DE
• Ines Herrmann · Munich, DE
• Ralf Lutterbüse · Munich, DE
• Elisabeth Nahrwold · Munich, DE

Key dates

• Filing date: Jul 31, 2015
• Grant date: May 30, 2023
• Expiry date: Mar 14, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T cell surface antigen CD3 via a second binding domain, wherein serum albumin is fused to the C-terminus of the antibody construct. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.