Processes for the production of tryptamines
US11661617B2 · kind B2 · utility
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10Claims
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Assignee
Inventor
Key dates
| Filing date | Sep 4, 2020 |
| Grant date | May 30, 2023 |
| Priority date | — |
| Expiry date | Sep 4, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y401/01
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.