Primers for immune repertoire profiling

US11661625B2 · kind B2 · utility

Assignee

• Becton, Dickinson and Company · US

Inventors

• Devon Jensen · San Jose, US
• Katherine Lazaruk · Redwood City, US
• Dennis Prosen · San Jose, US
• Ricelle A. Acob · San Jose, US
• Kai Liu · Taichang, CN

Key dates

• Filing date: May 13, 2021
• Grant date: May 30, 2023
• Expiry date: Aug 21, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6858
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed herein include systems, methods, compositions, and kits for immune repertoire profiling. There are provided, in some embodiments, primer panels enabling the determination of the nucleotide sequence of the complete variable region of nucleic acids encoding mouse B cell receptor (BCR) and T cell receptor (TCR) polypeptides. In some embodiments, the method comprises single cell transcriptomic analysis.