Parenteral nutrition formulation

US11666548B2 · kind B2 · utility

Assignees

• Baxter International Inc. · US
• Baxter Healthcare SA · CH

Inventors

• Laurent Jeannin · La Neuville, BE
• Mary Hise Brown · Vernon Hills, US
• Julien HECQ · Glattbrugg, CH
• Gary P. Zaloga · Winston-Salem, US
• Kelly Tappenden · Decatur, US

Key dates

• Filing date: Jun 5, 2020
• Grant date: Jun 6, 2023
• Expiry date: Jun 5, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations which are reconstituted from multi-chamber containers and amino acid formulations. More particularly, the present disclosure is directed to formulations comprising butyrate derivatives, specifically arginine butyrate, for use with adult or pediatric patients. The disclosure further provides for methods of reducing or preventing systemic and local inflammation of patients receiving parenteral nutrition, and methods of maintaining or ameliorating their systemic immunity and local immunity, as well as the patients' gut barrier functions.