Patent · US Active

Tetramaleimide linkers and use thereof

US11666623B2 · kind B2 · utility

0Cited by

1References

15Claims

0Family size

Assignee

NewBio Therapeutics, Inc. · CN

Inventors

Deqiang An · Shanghai, CN
Nianhe Han · Newbury Park, US
Peng Zhu · Tianjin, CN
Di Zeng · Shanghai, CN
Baoxiang Wang · Shanghai, CN
Huali Li · Shanghai, CN
Chun-Ying Yang · Taipei, TW

Key dates

Filing date	Apr 18, 2018
Grant date	Jun 6, 2023
Priority date	—
Expiry date	Apr 9, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D403/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.