Phenyl containing compound, intermediate thereof, preparation method therefor and application thereof

US11667604B2 · kind B2 · utility

Assignees

• SHANGHAI MODERN PHARMACEUTICAL ENGINEERING RESEARCH CENTER CO., LTD. · CN
• SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY · CN

Inventors

• Jun He · Guiyang, CN
• Zhefeng Wang · Shanghai, CN
• Yuezhu Zhao · Shanghai, CN
• Yani Yang · Shanghai, CN
• Qinghui Fu · Shanghai, CN
• Wei BIAN · Qingdao, CN
• Yuan Zhao · Mesa, US
• Chen Ge · Shanghai, CN
• Yue Zhang · Tianjin, CN
• Bing Yi · Shanghai, CN
• Minghao Niu · Shanghai, CN
• Jiuhui Zhang · Shanghai, CN

Key dates

• Filing date: Jul 14, 2020
• Grant date: Jun 6, 2023
• Expiry date: Jul 14, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A phenyl-containing compound, an intermediate thereof, a preparation method therefor and an application thereof. Provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy or C(═O)OR8; where R8 is C1-C4 alkyl; R6 is (II), (III) or (IV); and R7 is —OH, —NH2, —NHCH3, —N(CH3)2 or C1-4 alkoxy. The compound has a low critical micelle concentration (CMC) and good dilution resistance and is capable of enclosing an insoluble drug to form a small-molecule micelle having a high drug loading capacity and good stability.