Process for the preparation of highly pure Salcaprozic Acid and pharmaceutically acceptable salts thereof

US11667614B2 · kind B2 · utility

Assignee

• Navinta III Inc · US

Inventors

• Pankaj Vasudev Parmar · Vadodara, IN
• Raja Jeyakumar John Muthiah · Vadodara, IN
• Vikas Chauhan · Vadodara, IN
• Jagdish Kanjibhai Solanki · Vadodara, IN

Key dates

• Filing date: Apr 13, 2022
• Grant date: Jun 6, 2023
• Expiry date: Apr 13, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D265/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Processes that use novel reagents for the removal of colored impurity during the preparation of Salcaprozic Acid and pharmaceutically acceptable salts thereof. The processes include hydrolysis of 8-(2,4-dioxo-1,3-benzoxazin-3-yl)octanoic acid ethyl ester in the presence of or by contacting it with benzotriazole, hydrazine and/or sodium borohydride.