Synthetic system for tunable thresholding of protein signals

US11667676B2 · kind B2 · utility

Assignee

• CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

• Lucy S. Chong · Pasadena, US
• Ronghui Zhu · Sunnyvale, US
• Xiaofei Ge · Beijing, CN
• Michael B. Elowitz · Los Angeles, US
• Mark W. Budde · Arcadia, US

Key dates

• Filing date: Jan 9, 2020
• Grant date: Jun 6, 2023
• Expiry date: Feb 24, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/20
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.