Anti-MS4A4A antibodies and methods of use thereof

US11667699B2 · kind B2 · utility

Assignee

• Alector LLC

Inventors

• Jeonghoon Sun · Thousand Oaks, US
• Wei-Hsien Ho · Belmont, US
• Muhammad Abbas Alhawagri · San Francisco, US
• Philip Kong · San Francisco, US
• Herve Rhinn · New York, US
• Hua LONG · Redwood City, US
• Karpagam SRINIVASAN · San Jose, US
• Ananya MITRA · Menlo Park, US
• Daniel P. BERMINGHAM · San Francisco, US
• Klaus-Dieter HEGER · San Mateo, US
• Santiago Viveros SALAZAR · San Carlos, US
• Francesca CIGNARELLA · South San Francisco, US
• Ilaria TASSI · San Francisco, US
• Tina SCHWABE · San Francisco, US
• Angie Yee · San Francisco, US
• Arnon Rosenthal · Woodside, US

Key dates

• Filing date: Jul 30, 2020
• Grant date: Jun 6, 2023
• Expiry date: Jul 30, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.