Anti-human beta klotho antibody or binding fragment thereof and methods of their use

US11667708B2 · kind B2 · utility

Assignee

• NGM Biopharmaceuticals, Inc. · US

Inventors

• Kalyani Mondal · San Mateo, US
• Betty Chan Li · Millbrae, US
• Yu Chen · Foster City, US
• Taruna Arora · Palo Alto, US
• Hugo Matern · San Mateo, US
• Wenyan Shen · Redwood City, US

Key dates

• Filing date: Aug 28, 2020
• Grant date: Jun 6, 2023
• Expiry date: Aug 28, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides binding proteins, such as antibodies, and binding fragments thereof, that bind beta klotho, including human beta klotho, and exemplary specific sequences of their complementarity determining regions, variable regions, heavy chains, and light chains. The present disclosure also provides method of making the antibody or fragment thereof and methods of their use, including, in activating beta-klotho/FGF receptor complex, inducing FGF19-like and/or FGF21-like signaling, improving glucose and lipid metabolism, and treatment of nonalcoholic steatohepatitis.