5-membered and bicyclic heterocyclic amides as inhibitors of ROCK

US11673886B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Peter W. Glunz · Wilmington, US
• Vladimir Ladziata · Ewing, US
• Indawati De Lucca · Pennington, US
• George O. Tora · Langhorne, US
• Tarun Kumar Maishal · Bengaluru, IN
• Raghuram Tangirala · Secunderabad, IN
• Kamalraj Thiyagarajan · Vellore, IN

Key dates

• Filing date: Jun 17, 2021
• Grant date: Jun 13, 2023
• Expiry date: Jun 27, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.