Patent · US Active

Fractional regulation of transcription

US11674144B2 · kind B2 · utility

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0References

17Claims

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Assignee

CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

Michael B. Elowitz · Los Angeles, US
Lacramioara Bintu · Pasadena, US
John Yong · Sunnyvale, US

Key dates

Filing date	Apr 18, 2016
Grant date	Jun 13, 2023
Priority date	—
Expiry date	Dec 10, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/635
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method of controlling the number of cells in a population of cells having silenced transcription of a target nucleic acid as a function of time includes recruiting a chromatin regulator (CR) to a site proximal to a transcription initiation site of the target nucleic acid to form a fraction of silenced cells in the population of cells. The chromatin regulator may be EED, KRAB, DNMT3, HDAC4, EZH2, REST, or a combination thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.