Method for identifying kidney allograft recipients at risk for chronic injury

US11674181B2 · kind B2 · utility

Assignees

• ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · US
• WESTERN SYDNEY LOCAL HEALTH DISTRICT · AU

Inventors

• Barbara Murphy · Pelham Manor, US
• Weijia Zhang · Beijing, CN
• Philip J. O'Connell · Chatswood, AU

Key dates

• Filing date: Feb 1, 2021
• Grant date: Jun 13, 2023
• Expiry date: Jun 11, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method for identifying a renal allograft recipient at risk for chronic allograft damage or interstitial fibrosis and tubular atrophy (IF/TA) by comparing the transcription level of a preselected gene signature set with the transcription level of a comparison standard, and diagnosing the recipient as being at risk for chronic allograft damage if the transcription level of the preselected gene signature set is significantly higher than the transcription level of the comparison standard.