Methods for identifying and preparing pharmaceutical agents for activating Tie1 and/or Tie2 receptors
US11674959B2 · kind B2 · utility
0Cited by
18References
15Claims
0Family size
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Key dates
| Filing date | Aug 3, 2018 |
| Grant date | Jun 13, 2023 |
| Priority date | — |
| Expiry date | Jan 31, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention in various aspects and embodiments involves pharmaceutical compositions prepared by contacting a candidate α- or β-integrin-binding molecule, or panel thereof, with an integrin heterodimer, and quantifying heterodimer disruption by the candidate molecule. An integrin-binding molecule, or derivative thereof, that disrupts the integrin heterodimer is selected and is formulated into a pharmaceutical composition for administration to a subject, e.g., who has a disease or disorder related to abnormal vascularization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.