Aromatic heterocyclic compound, and pharmaceutical composition and use thereof

US11679108B2 · kind B2 · utility

Assignee

• GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. · CN

Inventors

• Jiancun Zhang · Dongguan, CN
• Qingan ZOU · 流花街道, CN
• Yanwei Chen · 安丰镇, CN
• Ning Kang · Morrisville, US
• Lijun Zhang · Los Altos Hills, US
• Yang Hu · Brookline, US
• Jufu Zhang · 流花街道, CN

Key dates

• Filing date: May 22, 2019
• Grant date: Jun 20, 2023
• Expiry date: May 22, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are novel heteroaromatic compound as an Autotaxin inhibitor, a pharmaceutical composition comprising the compound, and a use thereof in a treatment of a disease with a pathological feature of Autotaxin overexpression in a mammal, wherein the compound is according to formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitrogen oxide, metabolite, prodrug, or mixture thereof; wherein each of R1, Ar1, Ar2, Ar3, W, Y, Z, and Cy is defined in the present disclosure.