Caspase-3-triggered molecular self-assembling PET probes and uses thereof

US11679168B2 · kind B2 · utility

Assignee

• Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Jianghong Rao · Sunnyvale, US
• Yunfeng Cheng · Palo Alto, US
• Min-Che Chen · Amherst, US
• Jianghang Xie · Fremont, US
• Zixin Chen · Stanford, US

Key dates

• Filing date: Sep 13, 2019
• Grant date: Jun 20, 2023
• Expiry date: Sep 13, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.