Method for producing RNA molecule compositions

US11684665B2 · kind B2 · utility

Assignee

• CureVac SE · DE

Inventors

• Tilmann ROOS · Aspenhausiedlung, DE
• Martin Kunze · Rottenburg am Neckar, DE
• Benyamin YAZDAN PANAH · Tübingen, DE
• Salih YILMAZ · Biberach an der Riß, DE
• Markus CONZELMANN · Tübingen, DE

Key dates

• Filing date: Dec 22, 2016
• Grant date: Jun 27, 2023
• Expiry date: Oct 1, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing a ribonucleic acid (RNA) molecule composition comprising n different RNA molecule species, the method comprising a step of RNA in vitro transcription of a mixture of m different deoxyribonucleic acid (DNA) molecule species in a single reaction vessel in parallel, i.e. simultaneously, and a step of obtaining the RNA molecule composition. Also provided is the RNA composition provided by the inventive method and a pharmaceutical composition comprising the same as well as a pharmaceutical container. Moreover, the invention provides the RNA composition and the pharmaceutical composition for use as medicament.