Method for obtaining crystalline 2′-fucosyllactose

US11685759B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Michael Puhl · Hirschberg, DE
• Sebastian WLOCH · Ludwigshafen am Rhein, DE
• Peter Oedman · Neustadt, DE
• Anne-Catrin Letzel · Ludwigshafen am Rhein, DE
• Hartwig Schroeder · Greytown, ZA
• Jacek Malisz · Weil am Rhein, DE
• Daniel SEIBERT-LUDWIG · Ludwigshafen am Rhein, DE
• Emiel Jan KAPPERT · Ludwigshafen am Rhein, DE
• Chung Huan WONG · Mannheim, DE
• Michael Barros Gross · Ludwigshafen am Rhein, DE
• Martin Viertelhaus · Ludwigshafen, DE

Key dates

• Filing date: Oct 17, 2019
• Grant date: Jun 27, 2023
• Expiry date: Oct 17, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for obtaining crystalline 2′-fucosyllactose from a 2′-FL raw material, which contains 2′-FL as a main constituent and at least 0.5% by weight, frequently at least 1% by weight, in particular at least 2% by weight, more particularly at least 5% by weight, and especially at least 8% by weight,based on the total amount of mono-and oligosaccharides in the raw material, of one or more mono- or oligosaccharides different from 2′-FL, where the method comprises a)providing a solution of the 2′-FL raw material in water, which does not contain more than 10% by weight, preferably not more than 7% by weight, more preferably not more than 5% by weight of organic solvents, based on the total amount of water; b) effecting the crystallization of 2′-FL from the solution provided in step a) by inducing conditions of a controlled super saturation in the solution; and c) separating crystalline 2′-FL from the mother liquor, and where during controlled supersaturation in step b) not more than 10% by weight, preferably not more than 7% by weight, more preferably not more than 5% by weight of organic solvents are present, based on the total amount of water present…