Engineered heterodimeric proteins
US11685776B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Mar 1, 2018 |
| Grant date | Jun 27, 2023 |
| Priority date | — |
| Expiry date | Oct 22, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/66
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides heterodimeric antibodies and fragments thereof and methods for their preparation, wherein the pairing of heavy and light chains has been improved. Interface residues were mutated such that each light chain strongly favoured its cognate heavy chain when two different heavy chains and two different light chains were co-transfected and co-expressed in the same cell to assemble a functional, heterodimeric antibody or fragment thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.