Alkoxy pyrazoles as soluble guanylate cyclase activators

US11690848B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Judith Maria Ertle · Ingelheim am Rhein, DE
• Jochen Huber · Mittelbiberach, DE
• Ruediger Streicher · Biberach, DE

Key dates

• Filing date: Jul 9, 2019
• Grant date: Jul 4, 2023
• Expiry date: Jan 1, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P1/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein, for use in the treatment of diseases or disorders that can be alleviated by sGC activation or potentiation, selected from chronic liver diseases, Non-Alcoholic Steatohepatitis (NASH), cirrhosis and portal hypertension.