Vaccines formed by virus and antigen conjugation

US11690907B2 · kind B2 · utility

Assignee

• KBIO HOLDINGS LIMITED · GB

Inventors

• Steven D. Hume · Owensboro, US
• Leigh Burden · Owensboro, US
• Joshua D. Morton · Evansville, US
• Greg Pogue · Austin, US
• Barry Bratcher · Owensboro, US
• Hugh A. Haydon · Louisville, US
• Carrie A. Simpson · Evansville, US
• Nick Partain · Owensboro, US
• Youngjun Oh · Owensboro, US
• John W. Shepherd · Owensboro, US
• Michael H. Pauly · Del Mar, US

Key dates

• Filing date: Feb 26, 2021
• Grant date: Jul 4, 2023
• Expiry date: Mar 5, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/38034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods of forming compounds and exemplary stable compounds in the nature of a conjugated compound at refrigerated or room temperature, which in some embodiments comprises an antigen and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for use of the conjugate mixture as a vaccine, including but not limited to use as a vaccine against various pathogens including for treatment of diseases caused by novel coronaviruses (including SARS-COV 2).