Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells

US11690919B2 · kind B2 · utility

Assignees

• THE TEXAS A&M UNIVERSITY SYSTEM · US
• The Board of Regents of the University of Texas System · US

Inventors

• Elizabeth Sally Ward Ober · Dallas, US
• Raimund Johannes Ober · College Station, US
• Jeffrey Che-Wei KANG · Dallas, US
• Wei Sun · Brookline, US
• Ran Li · Beijing, CN

Key dates

• Filing date: Jan 17, 2018
• Grant date: Jul 4, 2023
• Expiry date: Aug 18, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Endolysosomal targeting conjugates that are engineered to deliver cargo molecules such as cytotoxic drugs or imaging labels with improved efficiency to late endosomes and/or lysosomes in target cells such as tumor cells are described. The endolysosomal targeting conjugate includes a targeting component and a cargo component. The targeting component is configured to bind to a cell surface molecule of a target cell and the cargo component includes a cargo molecule. The targeting component and the cargo component may be fused by a covalent bond or associated by a non-covalent bond. The targeting component may bind to the cell surface molecule or the cargo component with higher affinity in the extracellular space than in an endolysosomal compartment of the target cell.