Macrocyclic indoles as Mcl-1 inhibitors

US11691989B2 · kind B2 · utility

Assignees

• ASCENTAGE PHARMA (SUZHOU) CO., LTD. · CN
• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US
• ASCENTAGE PHARMA GROUP CORP LIMITED · CN

Inventors

• Hao Chen · Columbia, US
• Wenming Chen · Xinmin, CN
• Chao Li · 安丰镇, CN
• Dongbo Li · Suzhou, CN
• Yu Jing · Suzhou, CN
• Guozhi Tang · Shanghai, CN
• Yunlong Zhou · Suzhou, CN
• Shaomeng Wang · Saline, US
• Chao-Yie Yang · Hangzhou City, CN

Key dates

• Filing date: Nov 20, 2019
• Grant date: Jul 4, 2023
• Expiry date: Nov 20, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R1a, R1b, R1h, L2, L3, #, #, # are as defined as set forth in the re) specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.