Delivery of biomolecules to PBMCs to modify an immune response

US11692168B2 · kind B2 · utility

Assignee

• SQZ Biotechnologies Company · US

Inventors

• Armon R. Sharei · Watertown, US
• Howard Bernstein · Cambridge, US
• Scott LOUGHHEAD · Watertown, US
• Matthew BOOTY · Cambridge, US
• Katarina BLAGOVIC · Cambridge, US
• Kelan HLAVATY · Belmont, US
• Defne YARAR · Watertown, US
• Emrah Ilker OZAY · Watertown, US
• Carolyne Kelly SMITH · Waltham, US

Key dates

• Filing date: Feb 27, 2020
• Grant date: Jul 4, 2023
• Expiry date: Sep 6, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides peripheral blood mononuclear cells comprising an antigen, methods of manufacturing such PBMCs, and methods of using such PBMCs, such as for modulating an immune response in an individual. In some embodiments, the PBMCs are conditioned by incubating the PBMC in the presence of an adjuvant.