Xylose isomerases that confer efficient xylose fermentation capability to yeast

US11692187B2 · kind B2 · utility

Assignees

• VIB VZW · BE
• Katholieke Universiteit Leuven, KU LEUVEN R&D · BE
• GlobalYeast N.V. · BE

Inventors

• Johan Thevelein · Blanden, BE
• Mekonnen Demeke · Leuven, BE
• Maria Remedios Foulquié Moreno · Brussels, BE
• Stijn De Graeve · Egenhoven, BE
• Edgard Valdomiro Charles Belo · Heverlee, BE

Key dates

• Filing date: Dec 21, 2017
• Grant date: Jul 4, 2023
• Expiry date: Sep 10, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02E50/10
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to novel nucleic acid sequences encoding bacterial xylose isomerases that upon transformation of a eukaryotic microbial host cell, such as yeast, to confer to the host cell the ability of isomerising xylose to xylulose. The nucleic acid sequences encode xylose isomerases that originate from bacteria such as Eubacterium sp., Clostridium cellulosi and others. The invention further relates to fermentation processes wherein the transformed host cells ferment a xylose-containing medium to produce ethanol or other fermentation products.