Modulating expression of polypeptides via new gene switch expression systems
US11692194B2 · kind B2 · utility
1Cited by
15References
32Claims
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Key dates
| Filing date | Jan 10, 2018 |
| Grant date | Jul 4, 2023 |
| Priority date | — |
| Expiry date | Jan 10, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are polynucleotides encoding ligand-inducible gene switch polypeptides, and systems comprising gene switch polypeptides for modulating the expression of a heterologous gene and an interleukin in a host cell. The compositions, methods and systems described herein facilitate ligand dependent expression of polypeptides including but not limited to cytokines and antigen binding polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.