Compounds and methods for scavenging dicarbonyl electrophiles

US11696903B2 · kind B2 · utility

Assignees

• VANDERBILT UNIVERSITY · US
• THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS · US

Inventors

• Keith T. Wilson · Nashville, US
• John A. Oates · Nashville, US
• Olivier Boutaud · Nashville, US
• Venkataraman Amarnath · Nashville, US
• Erica Carrier · Nashville, US
• Alain Gobert · Rueil-Malmaison, FR

Key dates

• Filing date: Jun 4, 2020
• Grant date: Jul 11, 2023
• Expiry date: Oct 25, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.