Buffer-free, stable ophthalmological compositions of ketorolac and phenylephrine and applications thereof

US11696910B2 · kind B2 · utility

Assignee

• Somerset Therapeutics, LLC · US

Inventors

• Mandar V. Shah · Rockaway, US
• Kumaresan Parthasarathi
• Ilango Subramanian · Pequest, US
• Veerappan Subramanian · Mendham, US
• Aman Trehan

Key dates

• Filing date: Jul 23, 2022
• Grant date: Jul 11, 2023
• Expiry date: Jul 23, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/183
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides novel compositions comprising an anti-inflammatory agent and a mydriatic agent suitable for intraocular use, particularly ketorolac or pharmaceutically salts thereof and phenylephrine or pharmaceutically salts thereof, which are free of any buffering agent and yet, surprisingly, maintain stability for significant periods of time (e.g., at least about 3 months). The present invention also relates to a process of preparing such compositions and use thereof, e.g., in combination with intraocular ophthalmologic irrigation solutions.