Patent · US Active

Procedure for crystallization of (22E)-(24R)-2-methylene-22-dehydro-1α,24-25-trihydroxy-19-nor-vitamin D3

US11697635B2 · kind B2 · utility

0Cited by

9References

17Claims

0Family size

Assignee

Wisconsin Alumni Research Foundation · US

Inventors

Hector F. DeLuca · Deerfield, US
Margaret Clagett-Dame · Deerfield, US
Lori A. Plum · Madison, US
Agnieszka Flores · Madison, US
James B. Thoden · Madison, US
Hazel Holden · Fitchburg, US

Key dates

Filing date	Oct 16, 2018
Grant date	Jul 11, 2023
Priority date	—
Expiry date	Oct 16, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2602/24
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are methods of purifying the compound (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 in a solvent comprising ethyl acetate and hexane to form a solution, allowing crystals of (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 to form and precipitate from the solution, and recovering the crystals of (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 from the solution.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.