Method for preparing lornoxicam

US11697658B2 · kind B2 · utility

Assignee

• Beijing Jincheng Taier Pharmaceutical Co., Ltd. · CN

Inventors

• Zhen Liu · Taipei, TW
• Dongye Xing · Beijing, CN
• Zhongzheng ZHANG · Beijing, CN
• Jie Li · Shanghai, CN
• Yangong Han · Beijing, CN
• Yali Cui · Beijing, CN
• Liru Wang · Beijing, CN
• Hongliang Liu · Qinzhou City, CN
• Yan Mi · Beijing, CN
• Li Li · Spring, US
• Jingang Tang · Beijing, CN
• Yi Kang · Sichuan, CN

Key dates

• Filing date: Jul 23, 2021
• Grant date: Jul 11, 2023
• Expiry date: Nov 12, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to the technical field of drug synthesis, in particular to a method for preparing lornoxicam. The method includes the following steps: using 6-chloro-4-hydroxy-2-methyl-2-H-thieno[2,3-e]-1,2-thiazine methyl carboxylate-1,1-dioxide and 2-aminopyridine as raw materials, and xylene as a solvent; mixing the raw material and solvent, and adding a stabilizer, to obtain a mixture; subjecting the mixture to an ammonolysis; cooling the resulting reactant; conducting a vacuum concentration to remove the solvent; adding an organic solvent and slurrying, and filtering, to obtain a crude lornoxicam; and refining the crude lornoxicam to obtain the lornoxicam. In the present disclosure, p-toluenesulfonic acid is used as a stabilizer to reduce the reaction temperature and promote the reaction to proceed forward, thereby improving the quality and yield of the product.