Patent · US Active

Enhanced differentiation and maturation of pluripotent stem cell-derived myogenic cells

US11697798B2 · kind B2 · utility

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0References

8Claims

0Family size

Assignee

Regents of the University of Minnesota · US

Inventors

Rita Perlingeiro · Okabena, US
Sridhar Selvaraj · Minneapolis, US
Ricardo Mondragon Gonzalez · Estado de México, MX

Key dates

Filing date	Dec 13, 2018
Grant date	Jul 11, 2023
Priority date	—
Expiry date	Dec 1, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/45
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A method to increase the efficiency of myotube generation and maturation from pluripotent stem cells comprising: (a) differentiating pluripotent stem cells to myogenic progenitors; and (b) terminally differentiating said myogenic progenitors from (a) into myotubes in the presence of at least one gamma secretase inhibitor, wherein myotube generation is increased in the presence of at least one gamma secretase inhibitor, as compared to differentiation in the absence of gamma secretase inhibitors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.