Pharmaceutical compositions and methods of use for activation of human fibroblast and myofibroblast apoptosis
US11697813B2 · kind B2 · utility
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Key dates
| Filing date | Oct 30, 2017 |
| Grant date | Jul 11, 2023 |
| Priority date | — |
| Expiry date | Feb 1, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The current invention provides a method of activating fibroblast and myofibroblast apoptosis in a tissue of a mammal, comprising administering to the tissue a therapeutically effective amount of a composition comprising an siRNA molecule that binds to an mRNA that codes for TGFB1 protein in a mammalian cell, an siRNA molecule that binds to an mRNA that codes for COX-2 protein in a mammalian cell, and a pharmaceutically acceptable carrier comprising a pharmaceutically acceptable histidine-lysine polymer. The invention also provides additional methods for using this composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.