Controllable transcription
US11697823B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 24, 2017 |
| Grant date | Jul 11, 2023 |
| Priority date | — |
| Expiry date | Aug 30, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a stable method for introducing at least one inducible cassette into a cell, and permitting controllable transcription from within that inducible cassette. The method may be used for any cell type, from any eukaryotic organism, but has a particular application in the introduction of inducible cassettes into pluripotent stem cells, such as animal or human pluripotent stem cells (hPSCs). The inducible cassette is controllably inserted in such a way to ensure that the genetic material it contains is not silenced or subject to negative influences from the insertion site, and transcription of the genetic material is controlled.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.