Methods for detecting AAV
US11698377B2 · kind B2 · utility
3Cited by
6References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 14, 2017 |
| Grant date | Jul 11, 2023 |
| Priority date | — |
| Expiry date | Aug 8, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/075
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.