Patent · US Active

Use of multivariate analysis to assess treatment approaches

US11699530B2 · kind B2 · utility

0Cited by

5References

9Claims

0Family size

Assignee

Rensselaer Polytechnic Institute · US

Inventors

Juergen Hahn · Darmstadt, DE
Troy Vargason · Troy, US
Uwe Kruger · Mühlheim an der Donau, DE

Key dates

Filing date	Dec 11, 2019
Grant date	Jul 11, 2023
Priority date	—
Expiry date	Dec 11, 2039

Classification

Technology area (CPC G)Physics
CPC primaryG06F18/21324
WIPO fieldMedical technology
WIPO sectorInstruments

Abstract

Fisher discriminant analysis is performed on data sets of typically developing (TD) individuals and data sets of autism spectrum disorder (ASD) individuals to produce a model that classifies TD individuals from ASD individuals. The ASD data sets include pre-treatment folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathway metabolic profile data and post-treatment folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathway metabolic profile data for patients receiving one or more ASD treatments. Changes in adaptive behavior are predicted by utilizing regression of changes in adaptive behavior and changes in biochemical measurements observed in the data sets. Thus, the system can be used to predict the effectiveness of a given course of treatment for an ASD patient based on measured metabolite data of that patient, or to predict the overall effectiveness of a clinical trial based on metabolite data for the trial participants.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.