Short-acting heparin-based anticoagulant compounds and methods

US11701380B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Jian Liu · Los Angeles, US
• Zhangjie Wang · Changchun, CN
• Po-Hung Hsieh · Pasadena, US
• Yongmei Xu · Durham, US

Key dates

• Filing date: Mar 12, 2018
• Grant date: Jul 18, 2023
• Expiry date: Mar 12, 2038

Classification

• Technology area (CPC —): General

Abstract

Heparin compounds and synthetic heparin analogues having short acting anticoagulant activity are provided. Methods of synthesizing such heparin compounds, including chemoenzymatic pathways using sulfotransferase enzymes are provided. Methods of treating subjects in need of anticoagulant activity are provided.