Patent · US Active

Chimeric antigen receptors and methods for reducing toxicity

US11701405B2 · kind B2 · utility

0Cited by

0References

7Claims

0Family size

Assignee

City of Hope · US

Inventors

Xiuli Wang · Beijing, CN
Stephen J. Forman · Duarte, US
Lawrence Stern · Duarte, US
Christine E. Brown · Duarte, US
Joseph Cohen · Brussels, BE

Key dates

Filing date	Jan 25, 2019
Grant date	Jul 18, 2023
Priority date	—
Expiry date	Feb 27, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/622
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3ζ signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.