Patent · US Active

Antibodies specific for sclerostin and methods for increasing bone mineralization

US11702468B2 · kind B2 · utility

0Cited by

63References

2Claims

0Family size

Assignee

UCB PHARMA S.A. · BE

Inventors

David G. Winkler · Arlington, US
Jiye Shi · Slough, GB
John Latham · Seattle, US

Key dates

Filing date	Aug 28, 2019
Grant date	Jul 18, 2023
Priority date	—
Expiry date	Dec 1, 2039

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/4704
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.