Engineered antibodies and uses thereof

US11702480B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Bin Liu · Fishers, US
• Namkyung Lee · San Francisco, US
• Yang Su · South San Francisco, US
• Scott Bidlingmaier · San Francisco, US

Key dates

• Filing date: Nov 17, 2017
• Grant date: Jul 18, 2023
• Expiry date: Apr 13, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/574
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present disclosure relates to an engineered antibody that co-engages a cell type-selective (or specific) antigen (guide) and a signaling receptor (effector) on a target cell. In some instances, the engineered antibody is capable of modulating a signaling pathway on a target cell. In other embodiments, an engineered antibody of the present disclosure is administered to a subject for the treatment of a disease or condition.