Means and methods for staging, typing and treating a cancerous disease

US11702701B2 · kind B2 · utility

Assignees

• Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V. · DE
• Universität Regensburg · DE

Inventors

• Christoph Klein · Darmstadt, DE
• Sebastian Scheitler · Regensburg, DE
• Melanie Werner-Klein · Regensburg, DE
• Martin Hoffmann · Zwingenberg, DE
• Isabelle Hodak · Munich, DE

Key dates

• Filing date: Jan 27, 2017
• Grant date: Jul 18, 2023
• Expiry date: Aug 21, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods for diagnosing, staging and treating cancer, in particular melanoma. In particular, the present invention provides methods for determining the stage/type of a cancerous disease, comprising detecting somatic alterations of the DNA of one or more disseminated cancer cells (DCCs), obtained after homing to a distant organ, such as lymph node; and determining the somatic evolution of the DCC(s) based on the detected somatic alterations, wherein the somatic evolution is indicative of the stage/type of the cancerous disease.