Processes for preparing arimoclomol citrate and intermediates thereof

US11707456B2 · kind B2 · utility

Assignee

• KemPharm Denmark A/S

Inventors

• Zhe Zhang · Simpsonville, US
• Mark Read · Willoughby, US
• Elisabeth Vang Carstensen · Farum, DK
• Marco Poppe · Linz, AT
• Andreas Pelz · Linz, AT

Key dates

• Filing date: Mar 10, 2022
• Grant date: Jul 25, 2023
• Expiry date: Mar 10, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to a process for preparing arimoclomol, arimoclomol citrate and key intermediates, such as ORZY-01, thereof. The disclosure further relates to a process for preparing high purity arimoclomol citrate and methods of using the same.