Patent · US Active

Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof

US11708341B2 · kind B2 · utility

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28Claims

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Inventors

Matthew G. BEAVER · Natick, US
Sheng Cui · Lexington, US
Xiangqing Shi · Newbury Park, US

Key dates

Filing date	Aug 3, 2017
Grant date	Jul 25, 2023
Priority date	—
Expiry date	Mar 8, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D303/36
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure Compound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.